Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Identifieur interne : 000062 ( 1968/Analysis ); précédent : 000061; suivant : 000063Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Auteurs : Danuta M. Skowronski [Canada] ; Travis S. Hottes [Canada] ; Janet E. Mcelhaney [Canada] ; Naveed Z. Janjua [Canada] ; Suzana Sabaiduc [Canada] ; Tracy Chan [Canada] ; Beth Gentleman [Canada] ; Dale Purych [Canada] ; Jennifer Gardy [Canada] ; David M. Patrick [Canada] ; Robert C. Brunham [Canada] ; Gaston De Serres [Canada] ; Martin Petric [Canada]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Grippe humaine (immunologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Lymphocytes (immunologie), Mâle, Nourrisson, Nouveau-né, Pandémies, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Tests de neutralisation.
- MESH :
- immunologie : Grippe humaine, Lymphocytes, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Pascal (Inist)
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Pandémies, Réponse immune, Age, Infection, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Virus grippal A(H1N1).
English descriptors
- KwdEn :
- Adolescent, Adult, Age, Age Factors, Aged, Aged, 80 and over, Antibodies, Viral (blood), Antibody, Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Immune response, Infant, Infant, Newborn, Infection, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (virology), Influenzavirus A(H1N1), Lymphocytes (immunology), Male, Middle Aged, Neutralization Tests, Pandemics, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Lymphocytes.
- virology : Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neutralization Tests, Pandemics, Young Adult.
Abstract
Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.
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Affiliations:
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Pascal:11-0131918Le document en format XML
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<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
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<s3>CAN</s3>
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<country>Canada</country>
<wicri:noRegion>BC Biomedical Laboratories Ltd</wicri:noRegion>
</affiliation>
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<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
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<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1>
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<country>Canada</country>
<wicri:noRegion>Department of Microbiology and Immunology, University of British Columbia</wicri:noRegion>
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</author>
<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
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<author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
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<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
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<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
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</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
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<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
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<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
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<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
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<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Department of Pathology and Laboratory Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
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</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibody</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Immune response</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Infection</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Influenzavirus A(H1N1)</term>
<term>Lymphocytes (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lymphocytes (immunologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Lymphocytes</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
<term>Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Réponse immune</term>
<term>Age</term>
<term>Infection</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
<term>Virus grippal A(H1N1)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</noRegion>
<name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
<name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
<name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
<name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</country>
</tree>
</affiliations>
</record>
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